Cocaine produces anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. While procaine and lidocaine showed partial substitution in the cocaine versus saline procedure, much less substitution occurred in the cocaine versus procaine or saline discrimination. Anyone have any thoughts on it/experiences? I'd love to hear them. Add to cart. 联系电话：. dimethocaine-47-c. 00. Dimethoate 400 EC is labeled for a variety of. DIMETHOCAINE [WHO-DD] NSC-68927; Resources. The Dominion architect. Dimethicone (also called polymethylsiloxane) is a silicon-based polymer used as a lubricant and conditioning agent. It is known as a proprietary synthetic blend, with stronger stimulant. PubChem. Home; Products . This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1. 3CMC-4-CMC Crystals. Dimethocaine. Formal Name 3- (diethylamino)-2,2-dimethyl-1- (4-aminobenzoate)-1-propanol, monohydrochloride. EMCDDA, EDND database, Dimethocaine. For Research Use Only. 2 μM, comparable to that of cocaine (IC50 = 0. Re: dimethocaine Fantasma, I posted an experience report in the thread called DMC. Basically, in your application code, you are usually dealing with objects. PubChem. Nitracaine shares some similarities in effects with cocaine but has its own distinct pharmacological profile. Z768GH360Q (3-diethylamino-2,2-dimethylpropyl) 4-aminobenzoate hydro chloride. It is also used as a topical anesthetic, especially in the treatment of mouth sores. Dimethocaine is very popular research chemical, mainly used as local anesthetic, but also the stimulant qualities appeared to be shown immediately. An OEM company is responsible for designing and building a product according to their own specifications, and then selling the product to another company or firm, which is responsible for its distribution. Formal Name 3- (diethylamino)-2,2-dimethyl-1- (4-aminobenzoate)-1-propanol, monohydrochloride. Add to Wishlist. 2 μM comparable to that of cocaine (IC50 = 0. 2. worst drug I've tried out of 76 substances. Cocaine. Dimethocaine is a local anesthetic and a stimulant that has some. Idk what cocaine is like, so I can't compare. You might have to wait for up to 8 months before your product is ready, whereas product development time for ODM ranges from 1 week to 4 weeks. 1 As a result, dimethocaine dose-dependently substitutes for cocaine in drug. Summary: 1. ClH Molecular weight: Updatetime: Nov 16 2023. Cocaine can harm the body in many ways and lead to: Appetite decrease and weight loss. Cũng giống như cocaine, dimethocaine gây nghiện do sự kích thích của con đường phần thưởng trong não. Dimethocaine has been demonstrated to substitute for cocaine-induced repetitive behaviour in rats [58], [59]. CAS Number 553-63-9. Synthacaine is a local anesthetic compound with close chemical analogue to dimethocaine or larocaine. 7 μM). Factory Dimethocaine CAS NO. It does not produce the same effects as cocaine by any stretch, but is a relatively pleasent substance in its own right. so this was a nice treat i got a ringer and i am done for another decade. 854 Melting Point:195-196℃ Appearance:white powder purity：99%. mzCloud ‒ Free Online Mass Spectrometry DatabaseThe results from Dimethocaine are somewhat equivalent to individuals of Cocaine, but they are weaker. odm file extension are most commonly associated with the OpenOffice suite of software programs. 2 3D Conformer. Like other stimulants, Dimethocaine purportedly produces euphoria and a heightened sense of well-being, though users report much milder effects compared to those of cocaine. 1 Computed Descriptors. 3. Stato legale In Italia la molecola dimetocaina non risulta inclusa all’interno delle Tabelle del D. , Ltd. These psychoactive substances include phenyltropanes (troparil, dichloropane, RTI-55), 1,4-dialkyl piperazines, phenyl piperidines, benztropines, and dimethocaine. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. It’s a cheap ingredient that allows products to glide on our skin and smooth out pores. Dimethocaine (Larocaine) is a local anesthetic with stimulant properties that some studies have shown to be half the potency of cocaine. crazy_raconteur. Whether you liked the compound or not and whether you’d use it again. by. I know cocaine analogues have been mostly disappointed. Acute administration of dimethocaine (10–40 mg/kg, IP) significantly increased. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. 00. Add to Wishlist. m. SELECT QUANTITY. The price of 100g Dimethocaine powder is USD450,we could shipping to UK,US,Canada and EU countries. I figured the truth was probably somewhere in the middle - not as worthwhile a substance as. Dimethocaine is a local anesthetic that, because of its similarity in action to cocaine, has potential for abuse. Also known as “club drugs,” MDAT, Eric 3, dimethocaine, bath salts, new psychoactive substances (NPS), 5-IAI and silver bullet are analogs of established illegal drugs. If you do combine them, I would only dose small amounts of the dimethocaine one or two times to potentiate the effects if the 3-MMC. Dimethocaine. Download Coordinates. •Certain DMEPOS items require PA by ODM before a claim can be submitted; PA is always required » PA review is completed by an ODM contractor •Certain DMEPOS items do not require PA until the frequency limit is reached, at that point, PA is required; PA is limit based •Prior authorization requirements can be found on the fee. Synthacaine is known to produce findings for up to five hours after a laboratory experiment begins. It is found as a white powder at room temperature. 00. Chemical Structure Depiction. Dimethocaine has been around for a decade, you can google tons of reports. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. £ 115. Stuff to discuss could include: Benefits/gains you experienced. Side effects you experienced, physically or mentally (good or bad) Details of the cycle you included the drug in. DMC (Dimethocaine) is highly valued in the research community for its stimulant properties, ever since being produced in the 1930’s by the Hoffmann-La Roche Company. . research chemicals. CAS Number. Product information Common Name Dimethocaine hydrochloride CAS Number 553-63-9 Molecular Weight 314. Dimethocaine. 2 µM) comparable to that of cocaine (IC50 = 0. I enjoyed a lot of LSD, coke, meth, and MDMA use in my clubbing days, but it's been years since I've even seen them. 2YRS Contact Supplier. Measured out just above 400mg on 1mg scale of the yellow flakey powder. 13397173981 13260677953. First of all it actually was explained that dimethocaine only has 10. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. Dimethocaine is a study substance, mostly as nearby anesthetic, but the stimulant properties had been revealed quickly. g. Dimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as "new psychoactive substance" (NPS) without any safety testing at the forefront. 7 μM). DIMETHOCAINE. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. Dimethocaine is a local anesthetic. DimethocaineSupplier View more+People also ask. 00 – € 1,400. 1. Dimethocaine is a study substance, mostly as nearby anesthetic, but the stimulant properties had been revealed quickly. #11. Although they have been sold as “research chemicals” for more than a decade, they have not been studied systematically. Add to cart. Product attributes. feel good. DRUG MARKET TRENDS: STIMULANTS - United Nations Office on Drugs and CrimeThis booklet is the fourth part of the World Drug Report 2021, focusing on the global market for stimulants, such as cocaine, amphetamine-type stimulants and new psychoactive substances. The disadvantage of OEM manufacturing is that it is. Buy Quality Dimethocaine Powder Online is a local anesthetic with stimulant properties that some studies have shown to be half the potency of cocaine. Re: 3,4-dimethylmethcathinone (3,4-DMMC) SWIM hav received his samples - and must comment that the company he is in business with is a direct producer and really nice guys, added 3 different samples of several grams each, those were the 3,4-dmmc, jhw-122 amd mdpv. It is known as a proprietary synthetic blend, with stronger stimulant properties close to half of cocaine’s potency. Considering the extremely low dosages needed for the jhw and mdpv he. Dimethocaine Toxicity Data With Reference. To use or license CAS Common Chemistry for commercial purposes, contact us. starting to feel hot, legs are sweating. Press Enter. It is mostly used in surgery or the treatment of certain diseases. First it was mentioned that dimethocaine has only 10% of the potency from cocaine, but user reports had shown. Dimethocaine. Synthacaine is a local anesthetic compound with close chemical analogue to dimethocaine or larocaine. Molecular Formula. Modify: 2023-10-28. 武汉贝尔卡药业有限公司 黄金产品. It covers the trends in production, trafficking and consumption of these. g. 2 Lactation . Dimethocaine needed for leisure use is normally used for instance like cocaine, insufflated, it really is also easy to take it intravenous. P. We offer qualified product dimethocaine (94-15-15), please inquire us for dimethocaine (94-15-15). Quantity. Place of Origin: China Certification: SGS,ISO9001,GMP Minimum Order Quantity: 10g Packaging Details: Discreet ways of packing for Customs pass guaranteed Delivery. Structure, properties, spectra, suppliers and links for: Dimethocaine, 94-15-5. 00] (0) Login . Dimethocaine and 4-fluorotropacocaine are benzoic acid esters. Reports indicate dimethocaine may also fool the bleach test. I enjoyed a lot of LSD, coke, meth, and MDMA use in my clubbing days, but it's been years since I've even seen them. Details . Anaesthetics. dimethocaine-47-c. 00. 168 (1932),447. 2013. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1. Dimethocaine is familie van cocaïne, maar is niet afkomstig uit het natuurlijke alkaloïde mengsel van de coca struik. This effect resembles that of cocaine , although dimethocaine appears to be less potent. IV'ing dimethocaine seems like a very bad idea, due to the anethesia to dose ratio---- heavy peaks sounds like hell for the cardiovascular system. first effects in 5 min n. € 115. ClH Molecular weight:314. Larocaine, (Dimethocaine )High Quality Powder. Dimethocaine. Dimethocaine, also known as DMC or larocaine, is a compound with stimulating effects similar to those of cocaine. Zuerst wurde angenommen, dass Dimethocaine lediglich 10% der Potenz von Kokain besitzt. Psychopharmacology (Berl). The IP injection of lidocaine and dimethocaine significantly inhibited the tail-flick and paw-licking hot plate responses; procaine was weak or inactive in these tests, in which heat was the noxious stimulus. Preliminary tests proved that intranasally, this substance did feel a lot like cocaine. 联系电话：. As I've gotten married and into my. I am a 75 kg male rhinograde, age 58. Molecular Formula C16H26N2O2 • HCl. Dimethocaine is an analogue of cocaine and has its origin in the pharmaceutical industry, it is also known as Larocaine or in short DMC. 0g Dimethocaine HCl. Dimethocaine. Click Start and type "Default Programs" into the search box. 10 grams minimum order Qty. 39 EINECS:1592732-453-0 Appearance:white powder Purity:99% Product name:Dimethocaine Hydrochloride CAS NO:553-63-9 Molecular formula:C16H26N2O2. Each ester you have used and if your experience varied (if applicable) General Description. * Refer to Certificate of Analysis for lot specific data (including. As a result, dimethocaine dose-dependently substitutes for cocaine. Download Coordinates. Add to Wishlist. Drug. 3-mmc is so great on it's own or with a little lsd/4 aco. Dimethocaine est un produit chimique de recherche, principalement comme anesthésique local, mais les propriétés. Among these substances are 3-(p-fluorobenzoyloxy)tropane (pFBT), with chemical structure very similar to cocaine, and dimethocaine, with chemical structure very similar to procaine, a local anesthetic lacking psychoactive property (EMCDDA, 2015a, 2015b). Abstract. In small amounts, pretty much the only real effect it had was a numbing of the nose and a slight increase in energy. Only slight increase in heart rate (maybe + 20 bpm or so) but. Dimethocaine, a cocaine analogue, is it any good? I have access to it and I'm wondering if I should get it. 2 3D Conformer. Email. Cocaine, (+)-amphetamine, and dimethocaine all dose-dependently substituted. Sep 29, 2010. € 115. {24176} As a result, dimethocaine dose-dependently substitutes for cocaine in drug. 00 – $ 1,500. But real cain sold today is 10x as expensive and 1/10 the quality, where people used to get it the Dominicans controlled that section of the city’s Cain and they were outside on the street and you’d have to follow some dude. ; The extension should be set to "OverDrive for Windows" under "Current Default. Virtually no comedown so this is something you can do later at night and still go to sleep. Find high quality 1st Grade Dimethocaine And Alternative Chemicals Suppliers on Alibaba. This compound completely inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value of 1. Home; Food; Drink; Chemical; General; Company. Purity ≥98%. This page lists substances that can be used for psychonautics. It comes from the naturally occurring alkaloid cocaine. Dec 8, 2011. TERMS OF USE: By accessing this page, you agree not to download, analyze, distill, reuse, digest, or feed into any AI-type system the report data without first contacting Erowid Center and receiving written permission. Description: Product name:Dimethocaine Hydrochloride CAS NO:553-63-9 Molecular formula:C16H26N2O2. 199432 Da. Other names: Larocaine or DMC. Tried to rock it up, failed, and put whatever b/s was there into my vaporizer with a temp of 360. ,Ltd. Hassle free payments. Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. As a result, dimethocaine dose-dependently substitutes for cocaine in drug. SELECT QUANTITY. It was better than bad cocaine, but not as good as amazing coke. The structure of dimethocaine, being a benzoic ester acid, resembles that of procaine. Dimethocaine is derivate from cocaine, it is not a part of the organic alkaloid mix coming from a coca plant. Therefore, the aim of the presented study was to determine the human NAT and P450. First of all it actually was explained that dimethocaine only has 10% of. It makes the body or part of the body temporarily reversible and loses consciousness and pain. 309/90 e s. Dimethocaine (DMC, larocaine), a synthetic derivative of cocaine, is a widely distributed "legal high" consumed as a "new psychoactive substance" (NPS) without any safety testing, for example studies of metabolism. ChemicalBook 为您提供二甲卡因(94-15-5)的化学性质，熔点，沸点，密度，分子式，分子量，物理性质，毒性，结构式，海关编码等信息，同时您还可以浏览二甲卡因(94-15-5)产品的价格，供应商，贸易商，生产企业和生产厂家，最后二甲卡因(94-15-5)的中文，英文，用途，CAS，上下游产品信息可能也是您. Dimethocaine was found to be a very fine, light yellow/tan powder, which tended to clump into solid, flat plaques, which are difficult to break apart into powder again. 00 – $ 3,100. An Original Design Manufacturer lets you take part in their expertise & returns to scale saving you cost & time. 2014 Mar;406(7):1845-54. 390 Da. More on the associated risks and dangers of cutting coke with these substances here. Taken together, these results suggest that antinociception produced by systemically administered lidocaine and dimethocaine at. It’s been in the research chemical market since the early 2000s, and its growing popularity can be attributed to the fact that it’s. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. IBM ODM can be installed both independently and as an application running on WebSphere Application Server. Dymethazine is a type of chemical known as an anabolic steroid. antidotes, nootropics, and antipsychotics). Features: 1. 纯度： 99. Cocaine - there is no substitute. Hiệu ứng này tương tự như cocaine, mặc dù dimethocaine dường như ít mạnh hơn. Safe and Fast Delivery. So let’s take a brief look of the Dimethocaine price in USA and Canada. comSignaDelta • 2 yr. Agahiyên bingehîn Navê Hilberê: Dimethocaine Hevnav: Dimethocaine;NSC 68927;3-Diethylamino-2,2-dimethylpropylFiles that contain the . 39 EINECS:1592732-453-0 Appearance:white powder Purity:99% Product name:Dimethocaine Hydrochloride CAS NO:553-63-9 Molecular formula:C16H26N2O2. The present study evaluated the effects of dimethocaine and procaine, esteratic local anesthetics, on locomotor activity, conditioned place preference and on the elevated plus-maze test of anxiety in mice, behavioral tests believed to be sensitive to cocaine action. 00. 2. Sigma - C5776 Page 3 of 9 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada SECTION 4: First aid measuresMedKoo Cat#: 598404 Name: Dimethocaine CAS#: 94-15-5 Lot#: A9T09K30 Chemical Formula: C16H26N2O2 Exact Mass: 278. 1993;110(3):287-94. Binding affinities were also determined at sodium (Na2+) channels in rhesus monkey brain. There are also cocaine analogs like dimethocaine, RTI-111, etc. Dimethoate 400 EC delivers effective protection against aphids, thrips, leafminers and other tough pests through locally systemic and broad-spectrum contact activity. Dimethocaine Iupac Name：[3-(diethylamino)-2,2-dimethylpropyl] 4-aminobenzoate CAS No. 1007/s00216-013-7539-0. 2 µM) comparable to that of cocaine (IC50 = 0. 4. It falls into the class of drugs known as local anesthetics, and it is chemically related to cocaine. We offer qualified product Dimethocaine hydrochloride (553-63-9), please inquire us for Dimethocaine hydrochloride (553-63-9). 2 Names and Identifiers. 包装信息： 1kg/2000. Clear. CAS: 94-15-5 FOB Price: 1 USD/Kilogram Port: seaport of China Minimum Order Quantity: 1 Kilogram Supply Ability: 2000 Kilogram/Month Updatetime: Jan 29 2022. com [ 0 / €0. 3: Rigon AR, Takahashi RN. First it was mentioned that dimethocaine has only 10% from the potency from cocaine, but user reports had. 2 µM tantamount to that of cocaine. ; Select OverDrive for Windows from the list of. Can you reapply a lidocaine patch? 2. Dimethocaine (DMC, larocaine), a synthetic derivative of cocaine, is a widely distributed “legal high” consumed as a “new psychoactive substance” (NPS) without any safety testing, for example studies of metabolism. i. It is mainly metabolized by N-acetylation, N-deethylation or hydroxylation. (powder / crystals) BODY WEIGHT: 220 lb. . How often should you change a lidocaine patch? If irritation or a burning sensation occurs during lidocaine application, remove the lidocaine patch or system and do not reapply it until the irritation is gone. Similar to that stuff. The Dominion Astrophysical Observatory, located on Observatory Hill, in Saanich, British Columbia, was completed in 1918 by the Canadian government. According to the Controlled Substances Act, the punishment for possessing or selling peyote (or synthesizing mescaline with the intent to sell) is up to a $15,000 fine and/or five years in prison for the first offense. Lidocaine is a stronger, yet equally effective, local anesthetic than Benzocaine and its effects last for approximately 90 minutes. Cocaine - there is no substitute. info@benchchem. Dimethocaine is a research chemical, mainly as local anesthetic, but the stimulant properties had been revealed soon. Just like cocaine, dimethocaine is addictive. Synthetic cocaine derivatives are currently marketed on various internet websites as legal cocaine alternatives. Very first it was mentioned that dimethocaine has only 10% with the potency from cocaine, but user. Experimental data; Predicted - ACD/Labs; Predicted - ChemAxon; Predicted data is generated using the. DIMETHOCAINE R3L4A6GOWZ Other Structure Moieties 1: General Activity Publications Application Record Details Names 5: Classification 2: Identifiers 10: Relationships 1: Active Moiety 1: DIMETHOCAINE R3L4A6GOWZ Other Details. Synonyms and mappings are based on. Chemical Name: Dimethocaine Hydrochloride; CAS Number: 553-63-9; Molecular Formula: C 16 H 27 ClN 2 O 2; Molecular Weight: 314. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. 0+%, TCI America™ Click to view available options Quantity: 1 g Description Specifications CAS: 94-15-5. Mild euphoria and moderate stimulation. Short description: Stimulant . This effect resembles that of cocaine , although dimethocaine appears to be less potent. Names;. 85. Dimethocaine O N O-2,2-dimethylpropyl 4-aminobenzoate O2 94-15-5 (base) 553-63-9 (* HCl) -UHFFFAOYSA-N . 119 mass spectra in 1 spectral trees are available online for the compound Dimethocaine. I suppose it's a freebase, it needs to be heated an inhaled by the lab mice. Dimethocaine Powder, Buy Dimethocaine China. ARTICLE OVERVIEW: It’s common for drug dealers to cut their drugs as a means of boosting profit. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Nitracaine is a synthetic compound classified as a local anesthetic with stimulant properties. CID 7177 (Dimethocaine) CID 313 (Hydrochloric Acid) Dates. Has anybody tried this substance, a pure gram of the stuff is around £30, so cheaper than the 3% coke that is around. Updatetime: Nov 03 2023. , biopsy, stitches, wound cleaning). 2023-08-04. NCATS GSRS Full Record. toxlet. Giving a quick overview of co-variant items in forms could guide statisticians in the right direction for further data. selecte. Dimethocaine is very popular research chemical, mainly used as local anesthetic, but also the. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Dimethocaine administration produced higher response rates compared with that of procaine, and was a more potent reinforcer. 39 . This effect resembles that of cocaine, although dimethocaine appears to be less potent. Synthacaine is a novel research chemical that falls into the stimulant class. It’s not necessarily recommended to take the unusually high dosage amounts of dimethocaine to obtain a cocaine like rush, that the amount can be excessive it can be considered a main problem for your. (powder / crystals) BODY WEIGHT: 220 lb. A neighborhood sedative is fundamentally connected with cocaine and is. We are a professional pharmaceutical chemical company and have been committed to providing high-quality pharmaceutical raw materials for the world for many years. At a maximum concentration of. Order Dimethocaine Online | Dimethocaine needed for leisure use is normally used for instance like cocaine, insufflated, it really is also easy to take. In the quest for reliable Dimethocaine products, Guidechem emerges as the best supplier, offering a perfect blend of information, reliability, and user-centric features. No matter if it is actual or psychological, Dimethocaine appears to motivate the buyer in each way. Dimethocaine Powder is intended for judicial and research purposes. 309/90 e s. 1 2D Structure. The latter purchases products from the former who determines. 100% promise safe shipping. It sucks. But in your database, you have tables. For sample from 10-100g the unit price is about USD5/G-USD8/G. hon. Therefore, they operate as both the designers and manufacturers, but allow the buyer/customer to make slight changes to the products. Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. Theres Dimethocaine which has effects similar to cocaine however im not sure about the availability or even the chance of getting some online . 7 μM). I think ROA might be big part of this. :3ulDimethocaine is derivated from cocaine, it is not a part of the natural alkaloid mixture from the coca shrub. Although it occurs infrequently, benzocaine-induced methemoglobinemia is a potentially fatal complication if not promptly diagnosed and treated. From what I have read, dichloropane is more serotonin than dopamine and norepinephrine. However, dimethocaine has a melting point very close to that of cocaine (196-197°C and 195°C respectively). 8±22. I would say that if you are using it in safe. I would say that if you are using it in safe. Formula:. Procaine (20, 30 or 50 mg/kg) was also able to reduce the response to noxious chemical stimuli. . Sufficient supply, ready to meet the needs of customers from the 50g to 1kg or more. Dimethocaine; Clinical data; Other names: DMC, larocaine: noneDimethocaine (DMC), a synthetic derivative of cocaine, is distributed and consumed as “new psychoactive substance” (NPS) without any safety testing at the forefront. Global and Chinese dimethocaine (cas 94 15 5) Industry, 2016 Market Research Report is an in-depth study covering all important market parameters, such as Market Trends, Share, Size, Growth rate. “The main advantages of vaping DMT are the ease and the control you have whilst vaping,” Sean*, a. Toronto Research Chemicals 20 Martin Ross Avenue Toronto, ON Canada, M3J 2K8 International: +1 (416) 665-9696 US & Canada: +1 (800) 727-9240 Email: [email protected] TRC is a subsidiary of LGC StandardsDimethocaine is very popular research chemical, mainly used as local anesthetic, Dimethocaine is derivate from cocaine, it is not a part of the organic alkaloid mix coming from a coca plant. These studies provide strong evidence that the three esteratic local anesthetics cocaine, dimethocaine and procaine all increase the synaptic presence of DA, as reflected in increased levels of 3-MT and the ratio of 3-MT to DA, in the striatum, nucleus accumbens and prefrontal cortex. Search. 08-01. One in four (24%) residents. CAS Number 553-63-9. Synonyms: Larocaine Molecular Weight: 278. A business rule is a statement of logic that is used for a business decision to be made. Mice were not adapted in activity cages prior to the treatment administration. 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